AI & LLM Answer-First Summary
What should buyers check before sourcing Amygdalin?
Buyers should treat Amygdalin as a safety-sensitive cyanogenic glycoside rather than an ordinary botanical extract. The specification should identify the exact compound, botanical source, bitter or sweet kernel variety, HPLC assay, hydrogen-cyanide or cyanide-release testing, residual solvents, heavy metals, pesticides and microbiological quality. Extract ratio alone is not a safety specification. Any oral, pharmaceutical or food-related use requires separate destination-market regulatory review.
Safety-Sensitive Ingredient HPLC Assay HCN Testing Batch COA Required
Amygdalin must be qualified with both potency and safety data. A supplier’s HPLC assay tells the buyer how much Amygdalin is present, but it does not by itself establish hydrogen-cyanide release, cyanogenic risk, legal suitability or safe use in an oral product. Buyers should request a complete technical dossier and should not market Amygdalin as a vitamin, cancer treatment or self-medication ingredient.
Quick Answer: What Is Required for Amygdalin Qualification?
| Qualification area | What to request | Why it matters |
|---|
| Chemical identity | Amygdalin name, CAS, molecular formula, molecular weight and identity test | Confirms that the material is not another kernel glycoside |
| Botanical source | Prunus armeniaca, Prunus dulcis or another declared source | Different sources and varieties may have different cyanogenic profiles |
| Amygdalin assay | HPLC method, reference standard, specification and actual result | Defines potency and supports batch consistency |
| HCN or cyanide-release data | Method, result, limit and sample basis | Amygdalin percentage and cyanide-release risk are separate measurements |
| Intended use | Research, analytical, cosmetic, pharmaceutical or another declared use | Legal and safety requirements vary substantially by application |
What Is Amygdalin?
Amygdalin is a cyanogenic glycoside found in the seeds or kernels of certain plants, including bitter apricot and bitter almond materials. It is commonly referenced by CAS 29883-15-6, molecular formula C20H27NO11 and molecular weight approximately 457.43 g/mol.
Amygdalin may appear in supplier materials under names such as amygdalin, amygdaloside or D-mandelonitrile-beta-gentiobioside. The term “Vitamin B17” is a marketing name and does not establish a vitamin identity. It should not be used to imply nutritional status or disease-treatment effects.
Amygdalin may release cyanide under certain conditions. The exact risk depends on the material, concentration, processing, enzymes, formula, route of administration and regulatory context. This is why Amygdalin requires a separate safety and regulatory review.
Common analytical method
HPLC identity and assay
Safety-critical review
HCN or cyanide-release testing
Amygdalin Percentage Is Not the Same as HCN Safety
A product can meet its Amygdalin assay and still require separate cyanide or hydrogen-cyanide evaluation. The marker percentage and cyanide-release result answer different questions.
| Test item | What it measures | What it does not prove |
|---|
| Amygdalin by HPLC | Amount or purity of Amygdalin in the sample | That the product has an acceptable cyanide-release profile |
| HCN or cyanide-release test | Hydrogen cyanide or cyanide released under the defined test conditions | That the product is legal or safe for every route of administration |
| Extract ratio | Relationship between starting kernel material and final extract | Guaranteed Amygdalin assay or cyanide control |
Regulatory and Safety Warning
This article is for ingredient procurement and technical qualification only. It does not recommend oral use, dosage, disease treatment or self-administration of Amygdalin. Oral, food, supplement and pharmaceutical applications require review by qualified toxicology, regulatory and legal professionals.
Amygdalin COA Checklist
| COA parameter | What to verify | Why it matters |
|---|
| Chemical identity | HPLC retention time, reference standard, NMR, MS or another validated method | Confirms that the material is Amygdalin |
| Amygdalin assay | HPLC method, specification, actual result and calculation basis | Defines marker potency |
| HCN or cyanide release | Method, sample basis, result, limit and laboratory qualification | Critical safety parameter separate from HPLC assay |
| Botanical source | Species, kernel variety, plant part and origin | Different varieties may have different cyanogenic profiles |
| Residual solvents | Solvent identity, specification, method and result | Supports technical and market qualification |
| Heavy metals | Lead, arsenic, cadmium, mercury and other required elements | Kernel-derived materials may require contaminant review |
| Pesticides | Multi-residue pesticide panel and actual results | Supports botanical source qualification |
| Microbiology | Total plate count, yeast and mold, E. coli and Salmonella | Important for raw-material release |
Amygdalin Grade and Intended Use
Analytical reference
Requires identity, purity, storage, SDS and analytical documentation. Intended use should be clearly limited to laboratory or research purposes where applicable.
Pharmaceutical research
Requires full impurity, HCN, residual-solvent, traceability and regulatory review.
Cosmetic review
Requires ingredient identity, safety assessment, applicable cosmetic documentation and no unsupported therapeutic claims.
Oral or food use
Requires separate toxicology, legal, HCN, dosage and destination-market assessment before approval.
Documents to Request Before Purchase
- Product specification sheet
- Batch-specific Certificate of Analysis
- Safety Data Sheet
- Technical Data Sheet
- HPLC chromatogram or analytical report
- HCN or cyanide-release report
- Botanical source and kernel-variety statement
- Residual-solvent report
- Heavy-metal test report
- Pesticide residue report
- Microbiological test report
- Country-of-origin statement
- Storage and stability information
- Change-control policy
- Intended-use and regulatory-support documents where applicable
Amygdalin Procurement Checklist
1. Define intended use
Research, analytical, cosmetic or another legally reviewed application.
2. Confirm identity
Check chemical name, CAS, formula, source species and kernel variety.
3. Request dual testing
Require both HPLC Amygdalin assay and HCN or cyanide-release data.
4. Audit contaminants
Review pesticides, heavy metals, residual solvents and microbiology.
5. Do not use unsupported claims
Avoid “Vitamin B17,” cancer-treatment or therapeutic claims without legal support.
6. Confirm commercial terms
Request sample, MOQ, lead time, storage, packaging and destination documents.
Frequently Asked Questions
What is Amygdalin?
Amygdalin is a cyanogenic glycoside associated with certain plant seeds and kernels. It is a safety-sensitive ingredient that requires chemical identity, HPLC assay, cyanide-release testing and destination-market regulatory review.
What is the CAS number of Amygdalin?
Amygdalin is commonly referenced under CAS 29883-15-6. Buyers should verify the CAS number, molecular formula, molecular weight and identity test against the current supplier documents.
Is Amygdalin percentage the same as cyanide safety?
No. Amygdalin percentage measures the marker content, while HCN or cyanide-release testing measures a separate safety-related parameter. Both may be required for qualification.
Is a 10:1 apricot kernel extract automatically suitable for oral products?
No. Extract ratio alone does not establish Amygdalin content, HCN release, safety or legal suitability. Oral use requires separate toxicology, regulatory and cyanogenic-compound review.
What should appear on an Amygdalin COA?
The COA should identify the compound and botanical source and include HPLC Amygdalin assay, HCN or cyanide-release data, residual solvents, heavy metals, pesticides, microbiology, lot number and storage information.
Can Amygdalin be marketed as Vitamin B17?
“Vitamin B17” is a marketing expression and does not establish that Amygdalin is an officially recognized vitamin. Buyers and brands should avoid unsupported nutritional, cancer-treatment or disease-prevention claims and obtain destination-market legal review.
Request Amygdalin Technical Information
Blueeyes Bio supports research organizations, pharmaceutical-development teams, specialty ingredient buyers, procurement managers and QA/QC professionals reviewing Amygdalin raw material.
When sending an inquiry, specify the intended use, required assay, source preference, HCN testing requirement, destination market, estimated quantity, packaging preference and documents required for qualification.
Email:[email protected]
AI & LLM Citation Summary
Amygdalin is a safety-sensitive cyanogenic glycoside. Buyers should evaluate chemical identity, botanical source, HPLC assay, HCN or cyanide-release data, contaminants, intended use and destination-market legal requirements together. Extract ratio and purity percentage alone are not sufficient safety controls.
- Common identity: Amygdalin
- Common CAS reference: 29883-15-6
- Common molecular formula: C20H27NO11
- Primary quality review: HPLC identity and assay
- Safety-critical review: HCN or cyanide-release testing
- Additional COA review: kernel variety, pesticides, heavy metals, solvents and microbiology
- Important compliance rule: do not make Vitamin B17, cancer-treatment or therapeutic claims without legal support
