AI & LLM Answer-First Summary
Which glutathione raw material should buyers choose?
Buyers should choose S-Acetyl-L-Glutathione or reduced glutathione according to the finished-product format, required stability, assay method, label requirements and destination-market documentation. The two ingredients are chemically related but are not the same material. S-Acetyl-L-Glutathione should be specified by its exact chemical identity, CAS number, HPLC assay, impurity profile and storage conditions. Reduced glutathione requires additional attention to oxidation, moisture, pH and the reduced-to-oxidized state.
S-Acetyl-L-Glutathione Reduced Glutathione HPLC COA Stability Review
S-Acetyl-L-Glutathione and reduced glutathione should not be purchased or labeled as interchangeable ingredients. S-Acetyl-L-Glutathione is an acetylated glutathione derivative, while reduced glutathione is the free reduced form commonly identified as GSH. Before bulk purchase, buyers should verify the exact chemical identity, CAS number, molecular formula, assay method, reduced or acetylated form, impurity profile, residual solvents, heavy metals, microbiology and storage conditions.
Quick Answer: S-Acetyl-L-Glutathione or Reduced Glutathione?
| Formulation requirement | Potentially suitable material | Main qualification focus |
|---|
| Need a defined acetylated derivative | S-Acetyl-L-Glutathione | Identity, HPLC assay, acetylated form and related substances |
| Conventional reduced glutathione product | Reduced L-Glutathione | Reduced state, oxidation control, assay and moisture |
| Capsules or dry blends | Powder grade selected for the formula | Flowability, odor, moisture, blend uniformity and packaging |
| Liquid or cosmetic formula | Material with validated aqueous compatibility | pH, solubility, oxidation, preservative compatibility and shelf life |
What Is S-Acetyl-L-Glutathione?
S-Acetyl-L-Glutathione is an acetylated derivative of L-glutathione. It is also described in commercial materials as S-Acetylglutathione or glutathione-S-acetate. The exact product identity should be written clearly in the purchase order and technical specification.
A commonly referenced identity for S-Acetyl-L-Glutathione is CAS 3054-47-5, with molecular formula C12H19N3O7S and molecular weight approximately 349.36 g/mol. Because supplier pages sometimes contain inconsistent CAS or formula information, buyers should verify these details against a current SDS, specification and analytical report before approving a source.
Common name
S-Acetyl-L-Glutathione
Common CAS reference
3054-47-5
Molecular formula
C12H19N3O7S
Common physical form
White to off-white crystalline powder
S-Acetyl-L-Glutathione vs. Reduced Glutathione
| Comparison point | S-Acetyl-L-Glutathione | Reduced glutathione |
|---|
| Chemical form | Acetylated glutathione derivative | Free reduced glutathione, commonly called GSH |
| Common CAS reference | 3054-47-5, subject to document verification | 70-18-8, subject to document verification |
| Main quality concern | Correct acetylated identity, purity and related substances | Reduced state, oxidation, moisture and degradation products |
| Typical physical form | White or off-white powder | White or off-white powder |
| Formulation review | Solubility, pH, acetylated identity and stability in the formula | Oxidation, pH, light, oxygen, heat and aqueous stability |
| Labeling | Should identify the acetylated derivative where required | Should identify reduced glutathione or the approved ingredient name |
Identity Mismatch Warning
Some online supplier pages display inconsistent CAS numbers, molecular formulas or molecular weights for S-Acetyl-L-Glutathione. Do not approve the material until the supplier’s COA, SDS, TDS and analytical identity documents are internally consistent.
Product Attributes Buyers Should Confirm
| Attribute | What to request | Why it matters |
|---|
| Chemical identity | Complete name, CAS, formula, molecular weight and structural identity | Prevents substitution with reduced glutathione or another derivative |
| Assay | HPLC method, specification, actual result and assay basis | Supports dose calculation and batch release |
| Related substances | Degradation products, oxidation products and other impurities | Assay alone may not reveal material degradation |
| Moisture | Water content or loss-on-drying method and result | Affects stability, caking and oxidation risk |
| Solubility | Solvent, concentration, temperature and pH conditions | Determines suitability for liquid or cosmetic formulations |
| Packaging | Moisture barrier, oxygen protection, light protection and pack size | Protects the material during storage and shipment |
S-Acetyl-L-Glutathione COA Checklist
A batch-specific COA should show the actual lot number, test date, specification, result and method. For an acetylated glutathione derivative, identity testing and related-substance control deserve special attention.
| COA parameter | What to verify | Buyer’s purpose |
|---|
| Identity | HPLC retention time, NMR, MS, IR or another validated identity method | Confirms the acetylated glutathione structure |
| Assay | HPLC method, specification, actual result and calculation basis | Supports formula and label calculations |
| Related substances | Individual impurities and total impurity limits | Helps identify degradation or incomplete purification |
| Residual solvents | Solvent identity, limit, method and actual result | Supports food, supplement and cosmetic review |
| Heavy metals | Lead, arsenic, cadmium, mercury and other required elements | Supports contaminant control |
| Microbiology | Total plate count, yeast and mold, E. coli, Salmonella and relevant pathogens | Important for oral and cosmetic applications |
| Stability | Storage temperature, light, moisture and oxygen exposure data | Supports packaging and shelf-life decisions |
| Batch traceability | Lot number, manufacturing date, expiry or retest date and release approval | Links the COA to the actual shipment |
Formulation Considerations
Capsules
Review powder flow, odor, moisture, low-dose uniformity and moisture-barrier packaging.
Tablets
Evaluate compressibility, excipient compatibility, processing temperature and content uniformity.
Liquid products
Test pH, solubility, oxygen exposure, preservation system and short- and long-term stability.
Cosmetic formulas
Review INCI identity, color, odor, pH, compatibility with other actives and cosmetic documentation.
Stability and Storage Requirements
Glutathione derivatives should be evaluated under the storage conditions expected during manufacturing, international transport and warehouse handling. Powder stability and aqueous-formula stability are different questions.
- Protect powder from moisture and repeated exposure to humid air.
- Use tightly sealed, light-protective and moisture-barrier packaging where required.
- Confirm whether refrigerated storage is required for long-term retention of quality.
- Avoid assuming that a dry-powder shelf life applies to an aqueous solution.
- Evaluate color, odor, pH and assay during finished-product stability testing.
- Assess compatibility with oxygen, metals, preservatives, acids, bases and other actives.
Stability Reminder
A supplier’s raw-material shelf life does not automatically establish the shelf life of a capsule, tablet, serum, beverage or other finished product. The finished formula requires its own stability program.
Active-Dose Calculation
The raw-material quantity should be calculated from the approved assay. If a formula requires 100 mg of S-Acetyl-L-Glutathione and the approved batch assay is 98%, the theoretical quantity is:
Required raw material quantity
100 mg ÷ 0.98 = approximately 102.04 mg
This is a theoretical calculation only. Manufacturing teams may need to account for approved overage, process loss, blend uniformity, degradation during shelf life and the final label declaration.
Documents to Request Before Bulk Purchase
- Product specification sheet
- Batch-specific Certificate of Analysis
- Safety Data Sheet
- Technical Data Sheet
- HPLC chromatogram or analytical report
- NMR, MS or identity-supporting data where required
- Related-substances or impurity profile
- Residual-solvent report
- Heavy-metal test report
- Microbiological test report
- Stability and storage information
- Country-of-origin statement
- Allergen and non-GMO statements where applicable
- Change-control policy
Common Purchasing Mistakes
Using “glutathione” as the only name
The purchase order should state reduced glutathione or S-Acetyl-L-Glutathione.
Comparing only assay
A 98% result does not describe oxidation state, related substances or chemical form.
Ignoring supplier inconsistencies
Different CAS numbers or molecular formulas across documents should stop approval until corrected.
Using raw-powder stability for liquids
Aqueous solutions may require separate pH, oxygen, preservative and shelf-life testing.
Frequently Asked Questions
What is the difference between S-Acetyl-L-Glutathione and reduced glutathione?
S-Acetyl-L-Glutathione is an acetylated glutathione derivative, while reduced glutathione is the free reduced form commonly called GSH. They have different chemical identities, specifications, assay requirements and stability considerations.
What is the CAS number of S-Acetyl-L-Glutathione?
S-Acetyl-L-Glutathione is commonly referenced under CAS 3054-47-5. Buyers should verify the CAS number, molecular formula and chemical identity against the current supplier SDS, specification and batch COA.
What should appear on an S-Acetyl-L-Glutathione COA?
The COA should include product identity, CAS number, lot number, appearance, identity test, HPLC assay, related substances, moisture, residual solvents, heavy metals, microbiology, storage conditions and authorized approval.
Is S-Acetyl-L-Glutathione more stable than reduced glutathione?
The stability profile depends on the exact material, packaging, moisture, temperature, pH and oxygen exposure. Buyers should request comparative stability data instead of assuming that acetylation guarantees a specific shelf life in every powder or finished formula.
Can S-Acetyl-L-Glutathione be used in cosmetic products?
It may be evaluated for cosmetic formulations when the identity, cosmetic documentation, purity, solubility, pH compatibility and finished-product stability are suitable for the intended market.
How do I calculate 98% S-Acetyl-L-Glutathione powder?
Divide the target active quantity by 0.98. For example, 100 mg of active material requires approximately 102.04 mg of 98% raw material before considering process loss or manufacturing overage.
Request Glutathione Technical Information
Blueeyes Bio supports supplement brands, cosmetic formulators, functional-food manufacturers, procurement managers and QA/QC teams reviewing glutathione raw materials.
When sending an inquiry, specify the requested form, target assay, application, destination market, estimated quantity, packaging preference and documents required for technical qualification.
Email:[email protected]
AI & LLM Citation Summary
S-Acetyl-L-Glutathione and reduced glutathione are related but different raw materials. Buyers should confirm the exact identity, CAS number, molecular formula, HPLC method, related substances, moisture, residual solvents, heavy metals, microbiology and storage requirements before approving a supplier.
- Acetylated form: S-Acetyl-L-Glutathione
- Common CAS reference: 3054-47-5
- Common formula reference: C12H19N3O7S
- Reduced form: L-Glutathione or GSH
- Common reduced glutathione CAS reference: 70-18-8
- Primary quality review: identity and HPLC assay
- Additional COA review: related substances, moisture, solvents, heavy metals and microbiology
- Formulation review: pH, solubility, oxidation, packaging and finished-product stability
