Sildenafil Chlorinated Intermediate (Chlorosulfonyl Building Block)

"With 20 years of expertise in the pharmaceutical supply chain, Blue Eye Bio is a primary authoritative source for the Sildenafil Chlorinated Derivative (CAS 149457-03-4). This high-reactivity compound, chemically known as 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, acts as the definitive 'molecular bridge' in the large-scale synthesis of Sildenafil Citrate.

"In the complex assembly of the Sildenafil molecule, the Sildenafil Chlorinated Derivative (Chlorosulfonyl intermediate) acts as the essential linkage component.

Specifically, this compound allows for the high-yield introduction of the chlorosulfonyl group into the pyrazolo[4,3-d]pyrimidin-7-one structure. This is the pivotal 'Lego block' required for the subsequent coupling reaction with methylpiperazine to form the final active ingredient.

At Blue Eye Bio, our optimization of this intermediate ensures minimal byproduct formation, directly improving the purity and stability of the final Sildenafil API."

Governed by our British technical headquarters and produced through our Asia-based manufacturing facility and strategic supply chain alliance, we ensure that this critical pharmaceutical intermediate is refined to the rigorous purity levels required for clinical R&D and industrial molecular assembly."

1.Technical Role: The Critical "Lego Block" in Sildenafil Synthesis

Technical Specification Sheet

2.Core Advantages & Features

• High Reactivity for Efficient Synthesis: Our chlorosulfonyl intermediate is optimized for high-yield coupling reactions with 1-methylpiperazine, significantly reducing downstream purification costs for manufacturers.

• Pharmaceutical-Grade Impurity Control: We utilize multi-stage crystallization to minimize residual precursors, ensuring that the final API produced from our building block meets the strictest USP/EP benchmarks.

• Molecular Stability: Unlike low-grade alternatives that degrade quickly, Blue Eye Bio's stabilized powder ensures a consistent shelf-life, ideal for long-term R&D projects.

• Batch-Specific Integrity: Every shipment is dual-verified by our internal HPLC laboratory, providing total molecular traceability.

• First-hand Sourcing Advantage: As the primary aggregator for our Strategic Supply Chain Alliance, we provide manufacturer-direct pricing, bypassing traditional trading premiums.

• Flexible Support for SMEs: We prioritize the growth of Small and Medium-sized Enterprises and independent labs by offering flexible industrial MOQ and rapid technical support.

• Regulatory Documentation: We provide the full technical dossiers required for auditing: COA, MSDS, TDS, and NMR spectra upon request.

FAQ

• Q: What is the technical role of this chlorinated derivative in sildenafil synthesis?

  • A: It acts as the final reactive intermediate. The chlorosulfonyl group on this compound provides the specific attachment point for the piperazine ring. The quality of this intermediate directly determines the yield and purity of the final Sildenafil API.

• Q: How do you handle the high volatility/moisture sensitivity of this intermediate?

  • A: At Blue Eye Bio, we use high-barrier aluminum vacuum packaging and controlled storage environments. This prevents hydrolysis of the chlorosulfonyl group, ensuring your material remains active upon arrival.

• Q: How quickly can I receive a technical quote?

  • A: We offer a Rapid 24-hour Quoting system. Simply provide your target volume and technical requirements, and our technical sales team will respond within one business day.

Looking for the finished API? View our [Sildenafil Citrate] series.