Sildenafil-D3 with CAS 1126745-90-1 & Sildenafil-D8 with CAS 951385-65-2 (Analytical Standards)
Industrial Application: Indispensable as Internal Standards for LC-MS/MS; Used in Pharmacokinetic (PK) and drug metabolism studies to ensure analytical accuracy in clinical research.
Key Features: Exceptional isotopic purity; High chemical stability; Certified for laboratory analytical validation.
Strategic Edge: As a technical-driven partner, we offer these rare compounds with full isotopic characterization to support advanced Life Science R&D.
Sildenafil-D3 & Sildenafil-D8: Stable Isotope-Labeled Standards
Sildenafil Isotope-Labeled Standards: Precision in Bio-Analysis
1.Product Overview
Blue Eye Bio
specializes in providing high-precision Deuterated Reference Standards. Our Sildenafil-D3 and Sildenafil-D8 are specifically synthesized for advanced Bio-analytical testing. These stable isotope-labeled compounds are essential for laboratories requiring the highest level of isotopic and chemical purity for quantitative analysis
2.Technical Matrix
Sildenafil-D3 & Sildenafil-D8
Product Item | CAS Number | Isotopic Purity | Application |
Sildenafil-D3 | 1126745-90-1 | ≥ 99% Atom D | LC-MS Internal Std |
Sildenafil-D8 | 951385-65-2 | ≥ 99% Atom D | PK / Bio-analysis |
Chemical Structure Characteristics (Isotopic Labeling):These are deuterated compounds. By replacing specific hydrogen atoms in the molecular structure with stable deuterium atoms, they produce a significant mass shift in mass spectrometry.
Key Technical Specifications:
Chemical Purity: ≥ 98% - 99% (HPLC).
Isotopic Purity: ≥ 99% Atom D
Solubility: Soluble in DMSO, methanol, or acetonitrile; compatible with standard laboratory mobile phases
3.Industrial R&D Applications
Pharmacokinetic (PK) Studies: Used as a stable internal standard to track drug metabolism in complex biological matrices. It is used to study the absorption, distribution, metabolism, and excretion of drugs in organisms. Because D3/D8 is almost identical to regular sildenafil in chemical properties but has a different molecular weight, researchers can trace the metabolic pathways of drug molecules.
LC-MS/MS Bio-analysis: Providing precise quantification in mass spectrometry due to the distinct mass shift of deuterium labeling. This is the most crucial application. When detecting sildenafil concentration in blood or tissue fluid, conventional methods are inaccurate due to matrix effects. Adding Sildenafil-D3 or D8 as an internal standard can compensate for errors in the detection process, resulting in extremely accurate quantitative results. Bioequivalence - BE Testing： When developing sildenafil formulations, pharmaceutical companies must demonstrate that they have the same bioavailability as the original drug. This requires the use of high-quality isotope-labeled internal standards for comparison.
Toxicological Research: Ensuring high-fidelity results in forensic and clinical toxicology labs.
4.The Blue Eye Analytical Advantage
Unrivaled Isotopic Integrity: Our synthesis process ensures minimal un-labeled (D0) Sildenafil contamination, preventing analytical interference.
Comprehensive Characterization: Every batch is supplied with a detailed Certificate of Analysis (COA) including NMR, HPLC, and MS data.
Agile Sourcing: Leveraging our Strategic Supply Chain Alliance to provide rare analytical standards with rapid global fulfillment.
Custom Synthesis: Need a specific labeling pattern? Our Integrated Manufacturing Hub can facilitate bespoke isotope labeling projects.
Bespoke Packaging: We offer specialized low-volume vials (1mg, 5mg, 10mg) optimized for laboratory precision.
Rapid 24h Logistics: Real-time quoting and fast global shipping for time-sensitive research projects.
For laboratory use and R&D purposes only. Not for human or diagnostic use.
Q: What is the benefit of using D8 over D3 for sildenafil analysis?
A: Sildenafil-D8 provides a larger mass shift (+8 units), which further reduces the risk of overlapping with natural isotopes of the analyte, ensuring even higher precision in high-sensitivity LC-MS/MS assays.
Q: Do you provide a full characterization report with these standards? A: Yes. As a professional analytical standard supplier, Blue Eye Bio provides a comprehensive COA for every batch, detailing chemical purity, isotopic enrichment, and all relevant spectral data (H-NMR, MS).
Compliance & Support
